The Bethlahem Institute of Medical Sciences is located on a sprawling 12 acre eco-friendly serene campus at Nadutheri, a hamlet which is just 1 km from the Karungal bus station on the Karungal-Colachel Highway. It is 23 km from Nagercoil, the headquarters of Kanyakumari district and 52 km from Trivandrum, the capital of Kerala state. The Institute can be reached by bus via Colachel and Thuckalay / Marthandam. The nearest railway station is Kuzhithurai West.