UK DEMENTIA RESEARCH INSTITUTE

Working with Brains for Dementia Research, the UK Brain Banks Network and Alzheimer Scotland Dementia Research Centre, our team will develop a tissue resource of carefully selected, well-annotated and centrally managed brains with one hemisphere frozen and the other hemisphere fixed for microscopic analysis. Material from eight standardised sampling regions will be studied, both at the level of the single cell and by observing multi-cellular characteristics. As we establish the resource, we plan to tackle key, previously unanswered questions about tissue quality that will help refine similar studies in future. This will include how time between death and freezing of tissue impacts its quality and what is the best measure of tissue quality... A Multi-'omics Atlas Project - Alzheimer's Disease Aims Our Multi-‘omics Atlas Project (MAP) will use an unprecedented range of advanced techniques to examine tissue from eight different regions of the Alzheimer's Disease brain. This will gain a..