LEMIN LAB

1. Study on the effects of metabolic pathways on cardiovascular and cerebrovascular homeostasis and disease mechanisms. Cardiac and vascular functional homeostasis is closely related to their metabolic states, and metabolic pathways are widely involved in the occurrence and development of cardiovascular and cerebrovascular diseases (such as aneurysms, myocardial infarction, stroke, etc.). Metabolic regulation is an important research field after gene regulation and protein regulation. The team identified a variety of metabolic molecules and pathways involved in new pathophysiological mechanisms of cardiovascular disease and key target proteins, including macrophages activating inflammatory responses through the release of succinic acid; Cell connexin Cx43 maintains vascular endothelial barrier function by regulating NAD+ levels. In aneurysmal state, smooth muscle cells GSDMD mediated the release of putressin and phenotypic transition. New mechanisms of lipid metabolism such as apo(a)..

Primary location: Fuzhou China