BÜTTNER LAB

We are interested in different aspects of cellular aging and organellar connectivity. Using a combination of molecular and cell biology, genetics, biochemistry and imaging, we apply yeast as a model to understand age-associated cellular decay. The causes of aging are intertwined, and interdependent organelle subsystems and networks cooperate to sustain viability. Communication between organelles is ensured by dedicated signal transduction pathways or by direct physical contact at membrane contact sites. We are interested in contact dynamics in response to aging and altered metabolic regimes and the impact of organellar communication on cellular fitness and proteostasis over time.

Primary location: Stockholm