DMB LAB

Currently, there are more than 244,326 distinct structural domains as represented by the unique folds in the SCOP database. In order to annotate the functions of those structural domains, we present a database named Structural Domains Annotation Database. In the SDADB database, we gather heterogeneous information sources and integrated by a Bayesian network to obtain better result. The SDADB database not only present the structural domains and their annotations, but also include 3D structure alignment visualization, GO hierarchical tree view, search, browse and download options... Figure 1 shows the Framework of the SDA method which we use in this databases. For a query domain, annotations are predicted with four component methods: 1) structure-based method: protein-SCOP domain mapping information obtained from all-against-all structure alignment is used to calculate the probability that a domain annotated by a specific function; 2) InterPro-based method: InterPro domains of a SCOP..

Primary location: Changsha China