DRUG TARGET ONTOLOGY

Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO was developed as part of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg/overview), is supported by grant (IDG Knowledge Management Center, (U54CA189205). DTO is a novel semantic framework to formalize knowledge about drug targets and is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted and inferred class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development level classifications developed in the IDG project (https://druggablegenome.net/), and..