TRUELAB
Updated 28 days ago
Washington University School of Medicine Campus Box 8228 4566 Scott Ave Saint Louis, MO 63110
Prions are infectious proteins that were initially identified as the causative agent of certain neurodegenerative disorders in mammals called transmissible spongiform encephalopathies. Prion proteins harbor the ability to exist in structurally distinct states associated with functional alterations that undoubtedly have biological consequences. These proteins self-propagate an aggregated structure that converts protein from its native conformation to adopt the prion structure. While the applicability of the prion hypothesis is still debated for mammalian prions, it is clear that a similar process occurs in yeast...
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