CUSTODIOL

Custodiol® HTK Solution is intended for perfusion and flushing donor kidney, liver, heart, and pancreas prior to removal from the donor and for preserving these organs during hypothermic storage and transport to the recipient. It is based on the principle of inactivating organ function by withdrawal of extracellular sodium and calcium, together with intense buffering of the extracellular space by means of histidine/histidine HCI, so as to prolong the period for which the organs will tolerate interruption of blood and oxygen. Only a small portion of the osmolality of Custodiol® HTK Solution is due to sodium and potassium. Its composition is similar to that of extracellular fluid... Poor myocardial tolerance to prolonged cold ischemia remains a major concern in heart transplantation. In this study, we estimated superiority of Histidine-Tryptophan-Ketoglutarate (HTK) over University of Wisconsin (UW) as a cardiac preservation solution.

Also known as: Essential Pharmaceuticals, Essential Pharmaceuticals LLC

Primary location: Raleigh United States