SASLAB

1. Neuroinflammation, neuropil pathology, alterations of cerebral energy metabolism and glutamatergic neurotransmission in schizophrenia and affective disorders are a main focus of our research group... The typical long-term course of schizophrenia and affective disorders with onset in early adulthood, progressive as well as benign courses, exacerbations and remissions, shows similarities to various autoimmune disorders (e.g., multiple sclerosis, psoriasis, myasthenia gravis) and leads to the speculation of similar pathogenetic components. In addition to a well established neurodevelopmental component in the pathogenesis of schizophrenia, several MRI-studies reported a subtle progressive loss of brain tissue. This reduction of brain tissue without indications of neuronal loss seems to be caused by degenerative changes of neuropil or glial cells. In addition, several lines of evidence suggest that alterations in cerebral energy / glucose supply - which are closely linked with..