MCF-7 is a cell line that was first isolated in 1970 from the breast tissue of a 69-year old Caucasian woman. Of the two mastectomies she received, the first revealed that the removed tissue was benign. Five years later, a second operation revealed a malignant adenocarcinoma in a pleural effusion from which tissue was taken that would eventually result in the MCF-7 cell line. The donor was treated for breast cancer with radiotheraphy and hormonotherapy... MCF-7, a widely studied epithelial cancer cell line derived from breast adenocarcinoma, has characteristics of differentiated mammary epithelium. MCF7 cells can be used for detecting PI3K and MAPK involvment, along with easy detection of ERK and Akt phsophorylation. Also, via cytoplasmic estrogen receptors, these cells have the ability to process estradiol... MCF-7 cells are useful for in vitro breast cancer studies as a result of the cell line retaining several ideal characteristics particular to the mammary epithelium. These..