ALFORD LAB

Our lab takes a multimodal approach to understanding mechanotransduction and mechanoadaptation, or the ability of cells to adapt their function to changing mechanical conditions, in soft tissues. We employ microfabrication and novel biaxial testing approaches to probe the force-feedback behavior of cells and tissues. Combined with theoretical models, our approaches can be used to tease out the relationship between mechanical force and cellular responses, such as contraction, failure, and protein and gene expression... We are interested in a wide range of biomechanics problems including aneurysm formation and growth, cerebral vasospasm, and neurotrauma. Our goal is to determine the mechanisms of these mechotransduction-related dysfunctions to help guide future therapeutic strategies... A tradition of excellence Created in 1935, the College of Science and Engineering (formerly known as the Institute of Technology) brought together the University's programs in engineering, mining,..

Primary location: Minneapolis United States