MABTOX

The MABTOX consortium has combined know-how and expertise for leveraging novel technologies of enzymatically linking small molecule toxins to antibodies in a controlled fashion allowing precise control of toxin coupling site and ratio. This requires antibody engineering expertise to generate antibodies for enzymatic coupling, expertise in production of coupling enzymes, and expertise in synthesizing derivatives of small molecule toxins, that serve as substrates for the enzymatic coupling of toxins to antibodies. The combination of these three complementary expertises will result in the development of "next-generation" ADCs with expected better potency in cancer therapy with better controlled, moreefficient synthesis processes.

Primary location: Basel Belgium