FISER LAB

We are developing a computational approach to model proteins for which a limited number of experimental restraints are available. We utilize our recently developed fragment library of supersecondary structure elements (Smotifs) that was shown to have saturated almost 10 years ago. We hypothesize that all protein folds should be possible to build from this library. We are developing algorithms that take advantage of NMR checial shift information to identify a subset of Smotifs that form a protein and setting up optimization approaches that will rapidly assemble overlapping Smotifs into compact folds.

Primary location: Bronx United States